A Study to Assess the Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Rasagiline

Inclusion Criteria: 1. The subject is able to read, speak, and write in English or Japanese, as applicable. 2. The subject is able to understand and be willing to comply with the study requirements (eg, all dietary, exercise, tobacco, and alcohol restrictions) and provide written informed consent to participate in the study. 3. The subject is a man or woman, 20 to 50 years of age, inclusive. 4. The subject has a body mass index (BMI) of 18.0-28.0 kg/m2, inclusive. 5. The subject is in a good health, as determined by medical history, ECG, vital signs, physical examination, and clinical laboratory tests. 6. If female and of childbearing potential, the subject must have a negative β-hCG test at screening and a negative urine human chorionic gonadotropin (HCG) test at check-in and be willing and able to use one of the following medically acceptable double barrier methods of birth control from the screening visit through the end-of-study visit: non-hormonal intrauterine device with condom, diaphragm with condom, or condom with spermicide. Female subjects who are postmenopausal (1 year since last menses) must have elevated follicle stimulating hormone (FSH) level above 35 U/L, or be surgically sterile. 7. The subject must complete the screening process within 4 weeks before study drug administration. 8. The subject must be willing and able to comply with study restrictions and to remain at the clinic for the required duration during the study period, and willing to return to the clinic for the follow-up evaluation, as specified in this protocol. Additional inclusion criteria for Japanese subjects: 9. The subject was born in Japan and holds a valid Japanese passport. 10. The subject has 2 Japanese parents and 4 Japanese grandparents, as confirmed by interview. 11. The subject has been living outside of Japan for 10 years or fewer as confirmed by interview. Additional inclusion criterion for Caucasian subjects: 12. The subject has no parents or grandparents of Japanese descent as confirmed by interview. Exclusion Criteria: 1. The subject is a woman who is pregnant or lactating. 2. The subject has significant food or drug allergies or a known allergy or sensitivity to rasagiline or its derivatives or the formulation excipients. 3. The subject is unwilling to refrain from vigorous exercise (eg, strenuous or unaccustomed weight lifting, running, bicycling, etc) from 7 days before the first day of study drug administration until the final assessment. 4. The subject has had 1 of the following conditions in the noted amount of time before screening or at any time between screening and the first day of study drug administration: * major trauma or surgery in the last 2 months * acute infection in the last 2 weeks * malignancy within the last 5 years 5. The subject has a history of tuberculosis. 6. The subject has any condition that may interfere with drug absorption, distribution, metabolism, or excretion. 7. The subject is suffering from, or has a clinically significant history of, 1 or more of the following: cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, neurological, immunological, or psychiatric disorder(s), or a history of any illness that, in the opinion of the investigator, might confound the results of the study or pose additional risk to the subject if he or she participates in the study. 8. The subject has a positive test for hepatitis B surface antigen (HBsAg), hepatitis C antibody, or human immunodeficiency virus (HIV) antibody. 9. The subject has a history of hypertension or occasional increase of blood pressure, or any history of vascular structural abnormality. 10. The subject has a sitting blood pressure outside the range of 80 to 139 mm Hg (systolic) or 45 to 89 mm Hg (diastolic) (after at least a 5-minute rest) measured at screening. Blood pressure may be retested twice at intervals of 5 minutes. The blood pressure is considered sustained if either the systolic or diastolic pressure exceeds the stated limits in all 3 assessments. 11. The subject has used 1 of the following prohibited drugs or foods: * an investigational drug (new chemical entity) during the month prior to the first day of study drug administration * antidepressants, including selective serotonin reuptake inhibitors, tricyclic and tetracyclic antidepressants, within 42 days before the first day of study drug administration * MAO inhibitors, including reserpine and methyldopa, within 3 months prior to the first day of study drug administration * any medications (including over-the-counter \[OTC\] medications, vitamins, or herbal or nutritional supplements) within 14 days before the first day of study drug administration (except paracetamol/acetaminophen or ibuprofen used occasionally, up to 24 hours before the first day of study drug administration) * drugs known to significantly inhibit CYP1A enzyme drug metabolism within 14 days before the first day of study drug administration or drugs known to significantly induce human cytochrome P enzyme (CYP)1A drug metabolism within 28 days before the first day of study drug administration * excessive amounts of alcohol, defined as more than 3 drinks of alcoholic beverages (eg, beer, wine, or distilled spirits) per day in the last 3 months before the first day of study drug administration or a history of alcohol abuse * excessive amounts (equivalent to more than 6 cups of brewed coffee per day) of coffee, tea, cola, or other caffeinated beverages in the 3 months before the first day of study drug administration * grapefruit, Seville oranges, pomelo, or products made from them within 14 days before the first day of study drug administration until after the last day of pharmacokinetic sampling. * Other exclusion criteria apply.