The purpose of this study is to determine whether synthetic hernia mesh materials undergo physical and/or chemical changes while in the body.
Study Type
OBSERVATIONAL
Enrollment
111
Washington University School of Medicine
St Louis, Missouri, United States
Fibrosis level of explanted mesh
Each specimen will be graded and given fibrosis score of 0 - 4 to establish the degree of inflammation/foreign body reaction that occurred while mesh was in vivo.
Time frame: Within 2 weeks
Tensile strength of explanted mesh
Each specimen will be tested for tensile strength to determine force versus displacement.
Time frame: Within 2 weeks
Collagen protein levels of explanted mesh.
The total amount of collagen and non-collagenous proteins in cultured cell layers and tissue sections by differential staining with two dyes, sirius red and fast green. Sirius Red binds to all types of collagen, whereas fast green stains non-collagenous proteins.
Time frame: Within 2 weeks
Number of subjects with history of radiation to abdomen/pelvis
Identify possible clinical characteristics which affect mesh degradation.
Time frame: Within 2 weeks
Number of subjects with history of chemotherapy
Identify possible clinical characteristics which affect mesh degradation.
Time frame: Within 2 weeks
Number of subjects with corticosteroid/immunosuppression therapy
Identify possible clinical characteristics which affect mesh degradation.
Time frame: Within 2 weeks
Number of subjects with history of tobacco use
Identify possible clinical characteristics which affect mesh degradation.
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Time frame: Within 2 weeks