Comparison of Tamsulosin and Solifenacin in Treatment of Ureteral Stent Symptoms

Mansoura University131 enrolled

Overview

This study will be conducted to compare the effectiveness of alpha blocker (Tamsulosin) and Anticholinergic (Solifenacin) in relieving lower urinary tract symptoms caused DJ ureteral stents.

Eligible patients who signed the informed consent will randomly assigned to one of 3 groups; group 1 (control), group 2 (tamsulosin) and group 3 (Solifenacin). Ureteral stent symptom questionnaire (USSQ) will be used to compare health related quality of life scores.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

131

Conditions

Relieve of Ureteral Stent Symptoms

Interventions

TamsulosinDRUG

Patients in this arm will receive Tamsulosin 0.4 mg daily

SolifenacinDRUG

Patients in the arm will receive Solifenacin

ControlDRUG

Patients in this are will receive placebo

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patient who will undergo unilateral ureteral stent fixation: 1. To relieve upper urinary tract obstruction caused by ureteric calculi 2. After ureteroscopic lithotripsy for ureteral calculi. Exclusion Criteria: 1. Patients who had LUTS before stent fixation. 2. Ureteral stent fixation after open or laparoscopic surgery. 3. Bilateral ureteral stents. 4. Patients who developed complications related to the primary endoscopic procedure 5. Patients who developed stent related complications such as hematuria, acute pyelonephritis or stent displacement

Locations (1)

Urology and Nephrology Center

Al Mansurah, Egypt

Outcomes

Primary Outcomes

The Efficacy of tamsulosin and solifenacin in relieving ureteral stent symptoms will be evaluated by comparing the scores of ureteral stent symptoms questionnaire in the studied groups

Time frame: 1 year

Data from ClinicalTrials.gov

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