Bioavailability of Potassium From Potatoes and Potassium Gluconate

Purdue University45 enrolled

Overview

This study is designed to compare the effect of sources of potassium on uptake and the effect of potassium on blood pressure.

The study will compare uptake of potassium from three different doses and sources; supplements (720, 1440 and 2160 mg) potatoes (720, 1440 and 2160 mg) or French fries (2160 mg). During 9 phases, participants will consume a controlled diet with the supplements, potato or french fries (every other week for 5 days). On the 4th day, blood and urine samples will be taken to monitor potassium uptake and excretion. Measures of blood pressure will be analyzed at defined time points throughout the intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Potassium Bioavailability Blood Pressure

Interventions

Placebo controlDIETARY_SUPPLEMENT

Low dose potassium gluconateDIETARY_SUPPLEMENT

Medium dose potassium gluconateDIETARY_SUPPLEMENT

High dose potassium gluconate

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Able to adhere to the visit schedule, protocol requirements and available to complete the study * Normotensive men and women * Aged 20-60 years * BMI of 15-35 Exclusion Criteria: * Medication to treat hypertension or hypotension * Medication known to affect electrolyte metabolism or contain high levels of potassium or sodium * smoke cigarettes or use illegal drugs * Hypertension or hypotension * Diseases known to affect potassium metabolism * Pregnant * Allergic to nuts

Locations (1)

Purdue University

West Lafayette, Indiana, United States

Outcomes

Primary Outcomes

Bioavailability of Potassium

After 4 days of acclimation to the supplementation, absorption of potassium will be measured.

Time frame: 5 days

Secondary Outcomes

Blood Pressure Response to Potassium

Differences in blood pressure will be measured between levels of potassium consumption.

Time frame: 6 days

Data from ClinicalTrials.gov

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