Safety and Immunogenicity of Recombinant HIV Vaccines for HIV/AIDS

Inclusion Criteria: * Are willing to participate this study and available for follow-up for the duration of the study. * Men and women aged 18-50 years. * Are HIV-positive. * Have been taking stable anti-HIV drugs for at least 6 months. * CD4 count ≥ 350 cells/mm3 * Plasma viral load \< 50 copies/ml. * Willing to use acceptable forms of contraception at least 21 days prior to first vaccination until 56 days after the last vaccination. Exclusion Criteria: * Pregnancy or breast-feeding. * History of previous vaccination with an HIV-1 vaccine. * Use of immunoinhibitory agents, such as corticosteroids or cytotoxic drugs by oral administration, injection route or inhalation route within 6 months of study entry (But corticosteroids used for allergic rhinitis and skin topical application of corticosteroids were not included); Use of immunomodulatory agents including but not limited to interleukin-2(IL-2） and granulocyte-macrophage colony-stimulating factor (GM-CSF) within 30 days of study entry. * Use of blood products within 3 months of study entry. * Use of other experimental drugs within 3 months of study entry. * Any immunization within 3 months of study entry. * Comply with any of the following items： Active pulmonary tuberculosis； History of serious adverse reaction to other vaccines； Serious asthma； Have untreated thyroid disease; Syphilis * Laboratory values（Comply with any of the following items）: Hemoglobin \< 100 g/L (male subjects)，\<90 g/L (female subjects)； Absolute neutrophil count ≤ 1000 cells/mm3； Serum creatinine ≥15 mg/L，endogenous creatinine clearance rate \<50 ml/min； alanine aminotransferase（ALT）, aspartate aminotransferase(AST) ≥3× upper limit of normal range； Total bilirubin ≥2× upper limit of normal range * Clinically significant electrocardiogram changes. * Hypertension ( If it is well controlled by medication and is less than 150/100mmHg , should not be excluded) and other cardiac disease； * Any medical, psychiatric, social condition, occupational reason judged by the investigator that would limit the evaluation of a subject.