A Study of the Tolerability, Safety, and Pharmacokinetics of ISU302 in Healthy Volunteers

Inclusion Criteria: * Healthy male volunteers, aged between ≥ 20 and ≤ 45 years old * Weight ≥ 50, with calculated body mass index of 17 and 25 kg/m2 * BMI = (Weight \[kg\])/(height \[m\])2 * Subject is informed of the investigational nature of this study and voluntarily agrees to participate in this study and comply with the relevant instructions in written * Considered ineligible through screening test (such as medical history, physical examination, ECG, safety laboratory test) performed within 35 days prior to study start (dosing of investigational products) Exclusion Criteria: * With symptoms indicating acute diseases within 28 days prior to start of study (dosing of investigational product) * History or presence of clinically significant and active cardiovascular, respiratory, renal, endocrine, hematological, gastrointestinal, central nervous system, psychiatric disorder, autoimmune disease, or malignant tumor * Any medical history that may affect drug absorption, distribution, metabolism and excretion(e.g., inflammatory gastric disease, gastric or intestinal ulcer, hepatic or renal disease) * With presence of clinically significant allergic disease (including mild allergic rhinitis or allergic dermatitis which does not need medication) * With presence of clinically significant hypersensitivity to any drugs * With hemolytic anemia, anemia due to blood loss (Hb \< 14g/dL and Hct \<42%) * With the results of safety laboratory test 1. AST (Aspartate Transaminase) or ALT (Alanine Transaminase) \> 1.5 times of upper normal limit 2. Total bilirubin \> 1.5 times of upper normal limit * Subject who has immune deficiency or medication with immune suppressants * Participation in other clinical study within 60 days prior to start of study (dosing of investigational products) * Use of any drugs, possibly affecting drug metabolizing enzymes, within 1 month prior dosing, or any drugs, possibly affecting the results of clinical trial within 10 days or use of drug was not passes 5 x half-life of drug * Donated whole blood within 60 days, or transfused within 20 days before the study * History of alcohol abuse (\> 14 units/week) and the subject could not stop drinking alcohol beverage during study period * Heavy smoker (\>10 cigarettes/day) or the subject could not stop smoking during study period * Unwillingness or inability to follow the procedures outlined in the protocol * Positive in pregnancy test in urine and unwilling to follow contraception during study period and following 3 months (for female subjects).