Care Path for the Management of Ulcerative Colitis

Inclusion Criteria: * Females of child bearing potential must have a negative serum pregnancy test prior to randomization, and must use a hormonal (oral, implantable or injectable) or barrier method of birth control throughout the study. Females unable to bear children must have documentation of such in the source records -- - Documented diagnosis of UC with a Mayo Clinic Score (MCS) ≥6 and a baseline Mayo Endoscopy Score \>2. * Either an elevated serum C-reactive protein (CRP) (above the Upper Level of Normal (ULN) according to local laboratory results) or elevated fecal calprotectin (\> 250 mg/kg) concentration. * Requires sigmoidoscopic evaluation at baseline (standard of care) * Written informed consent must be obtained and documented. * Ability of subject to participate fully in all aspects of this clinical trial in the opinion of the investigator. Exclusion Criteria: * Previous failure of TNF antagonist therapy * Received any investigational drug in the past 30 days or 5 half-lives, whichever is longer. * Pregnant or lactating women. * Any conditions (e.g., history of alcohol or substance abuse) which in the opinion of the investigator, may interfere with the subject's ability to comply with study procedures.