Evaluation of Immune Signaling Networks in Healthy Human Volunteers

Martin Angst25 enrolled

Overview

The purpose of this study is to better understand whether and to what extent the activity of immune cells in blood varies over time under normal conditions as assessed in healthy subjects. Results of this study will provide the foundation for helping us evaluate changes in immune cell activities in response to surgery and drugs used in anesthesia. The overall purpose of our research is to understand immune health in the context of anesthesia and surgery.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Normal Immune Cell Function

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18-50 2. Good general health Exclusion Criteria: 1. Recent cold or flu 2. Chronic use of medications affecting the immune system 3. Chronic illness 4. Smoking habit 5. History of drug abuse 6. Current recreational drug use

Locations (1)

Stanford University

Stanford, California, United States

Outcomes

Primary Outcomes

Numerical and functional changes of circulating immune cells over time in healthy individuals

This is an exploratory study. Numerical and functional (phosphorylation of signaling molecules and transcription factors) behavior of all circulating immune cells will be captured. Blood specimens collected at referenced time points will be analyzed with mass cytometry.

Time frame: Day 1, Day 2, Day 7, Day 28

Data from ClinicalTrials.gov

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