Influence of Tracheostomy on Lung Deposition in Spontaneously Breathing Patient

Cliniques universitaires Saint-Luc- Université Catholique de Louvain9 enrolled

Overview

To compare lung deposition of amikacin in two settings: spontaneously breathing through a tracheostomy cannula and through the mouth.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Tracheostomized Patients

Interventions

Nebulization through the tracheostomyOTHER

Each subject received two nebulization sessions under spontaneous breathing in a sitting position. The first session was performed prior to tracheostomy removal. During the first nebulization, subjects inhaled the aerosol through the tracheostomy, cuff inflated and inner cannula removed.

Nebulization through the mouthOTHER

Each subject received two nebulization sessions under spontaneous breathing in a sitting position. The second nebulization was performed when the tracheostome was totally scarred. During the second nebulization, subjects inhaled the aerosol a mouth piece and wore a nose clip.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient who were likely to require an elective tracheostomy surgery as part as their head and neck surgery Exclusion Criteria: * Allergy to Aminoglycosides * Patients who received Aminoglycosides treatment less than one month prior the surgery * Pectoralis major flap reconstruction * Latissimus dorsi flap reconstruction

Locations (1)

Cliniques Universitaires Saint-Luc

Brussels, Belgium

Outcomes

Primary Outcomes

Amikacin urinary drug concentration

Time frame: At each micturition during 24 hours

Data from ClinicalTrials.gov

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