Effect of Aerobic Interval Training on Cardiovascular Function in Type 2 Diabetes

University of Florida116 enrolled

Overview

The study objectives are: 1. To compare cardiovascular function in type 2 diabetes patients vs. healthy controls. 2. To compare the effect of 8 weeks of aerobic interval training versus continuous moderate exercise on cardiovascular function in adults with type 2 diabetes. 3. To examine the mechanisms underlying the exercise-related changes in cardiovascular function. The investigators hypothesize that compared to continuous moderate intensity exercise training, interval training will be more effective in improving cardiovascular function in adults with type 2 diabetes.

Cardiovascular function will be measured at baseline in adults with type 2 diabetes and in age-matched healthy controls. Research volunteers with type 2 diabetes who meet the inclusion criteria will be randomized to the aerobic interval training group, continuous moderate exercise group or non-exercise control group. At the end of the 8-week randomized control exercise intervention, baseline measures will be repeated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

116

Conditions

Type 2 Diabetes

Interventions

High intensity aerobic interval trainingOTHER

Supervised aerobic interval training will be performed on bicycles 4 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax.

Continuous moderate intensity exerciseOTHER

Supervised exercise training will be performed on bicycles 4 times per week for 8 weeks. Each training session will last 47 minutes and will consist of continuous moderate intensity cycling at 70% of HRmax.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 79 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for type 2 diabetes : * Diagnosis of type 2 diabetes * Sedentary or minimally physically active for at least the prior 1 year * Able to give consent Inclusion criteria for healthy control group: * Sedentary or minimally physically active for at least the prior 1 year * Able to give consent Exclusion Criteria: * History of diabetic proliferative retinopathy, autonomic or peripheral neuropathy * History of any relevant cardiovascular diseases (myocardial infarction, angina pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart failure, or arrhythmia) * Hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic) * History of renal impairment * History of gout or hyperuricemia * History of hepatic disease or infection with hepatitis B, C * History of seizures, or other relevant on-going or recurrent illness * Recent (within 3 months) or recurrent hospitalizations * Use of tobacco products * \>5 % weight change in the prior 6 months. * Current intake of medications that may affect study results * Premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy. * Pregnancy (positive urine pregnancy test) or lactation * For the healthy control group, history of diabetes.

Locations (1)

University of Florida

Gainesville, Florida, United States