Effect of Aerobic Interval Training on Cardiovascular Function in Aging

University of Florida60 enrolled

Overview

Study objectives: 1. To compare cardiovascular function in older compared to young healthy adults. 2. To compare the effect of 8 weeks of aerobic interval training vs. continuous moderate exercise on cardiovascular function in healthy older adults. Hypotheses: 1. Compared to young adults, older adults will have lower cardiovascular function. 2. Compared to continuous moderate intensity exercise training, interval training will be more effective in improving cardiovascular function in older adults.

Cardiovascular function will be measured at baseline in older healthy adults and young healthy controls. Older adults will be randomized to the aerobic interval training group, continuous moderate exercise group or non-exercise control group. At the end of the 8-week exercise intervention, baseline measures will be repeated in the older adults.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Aging

Interventions

High intensity aerobic interval trainingOTHER

Supervised aerobic interval training will be performed on bicycles 4 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax.

Continuous moderate intensity exerciseOTHER

Supervised exercise training will be performed on bicycles 4 times per week for 8 weeks. Each training session will last 47 minutes and will consist of continuous moderate intensity cycling at 70% of HRmax.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 79 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for older adults: * Healthy men and women 55 to 79 years of age * Sedentary or minimally physically active for at least the prior 1 year. * Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years. * Premenopausal women will be eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle. * Able to give consent. Inclusion Criteria for young adults: * Healthy men and women 18 to 35 years of age * Sedentary or minimally physically active for at least the prior 1 year. * Women will be premenopausal, eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle. * Able to give consent. Exclusion Criteria: * history of diabetes * history of any relevant cardiovascular diseases (myocardial infarction, angina pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart failure, or arrhythmia) * hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic) * history of renal impairment * history of gout or hyperuricemia * history of hepatic disease or infection with hepatitis B, C * history of seizures, or other relevant on-going or recurrent illness * recent (within 3 months) or recurrent hospitalizations * use of tobacco products * \>5 % weight change in the prior 6 months. * current intake of medications that may affect study results * participation in regular aerobic exercise training (\>30 minutes, * 3 times/wk in the past year). * premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy. * pregnancy (positive urine pregnancy test) or lactation

Locations (1)

University of Florida

Gainesville, Florida, United States