Action of Epigenetic Modifiers in Cystic Fibrosis Treatment

General inclusion criteria : * informed consent * benefit from disease insurance regimen * men and women Inclusion Criteria for CF patients * 2 severe CF mutations * age superior or equal to 12 Inclusion Criteria for controls : * age superior or equal to 18 * no smoker (for 5 years) General exclusion criteria : * participation to an other interventionnal study * subject in exclusion period * law protected subject * pregnant and breast fooding Specific Exclusion Criteria: * Xylocaine hypersensibility * Porphyria * severe hepatic failure * Epilepsy * Severe cardiac failure * local anesthesic contra indication Specific Control subject Exclusion Criteria: * respiratory disease * cystic fibrosis * acute infection \< 6 weeks * on treatment * antibiotic treatment \< 3 months