A Phase 2a Study Followed to Evaluate the Safety, Tolerability and Levodopa Pharmacokinetics in Levodopa-treated Parkinson's Disease Patients Receiving ND0612

Inclusion Criteria: 1. Men and women with idiopathic Parkinson's disease 2. Subjects must experience motor fluctuations associated with LD/CD dosing 3. Modified Hoehn and Yahr stage \< 5 4. Subjects must be taking optimized and stable levodopa/dopa decarboxylase inhibitor therapy 5. Subjects who are treated with dopaminergic agonists and other anti-PD drugs should be on stable doses 6. Women must be postmenopausal, surgically sterilized, or using adequate birth control. Women of childbearing potential must have a negative pregnancy test (serum beta-HCG) at screening. 7. Subjects must be age 30 or older. 8. Subjects must be willing and able to give informed consent Exclusion Criteria: 1. Subjects treated with entacapone, tolcapone, stalevo or controlled release formulation of levodopa/carbidopa. 2. Subjects with a clinically significant or unstable medical or surgical condition 3. History of melanoma or significant skin disorders 4. Subjects with significant cognitive impairment 5. Subjects treated with unstable doses of dopaminergic agonists, anticholinergics, Monoamine oxidase (MAO)-B inhibitors, or antipsychotics 6. Subjects with clinically significant psychiatric illness 7. Subjects with a history of alcohol or substance abuse 8. Subjects who have taken experimental medications within 60 days prior to baseline. 9. Subject who have undergone a neurosurgical intervention for Parkinson's disease (e.g., pallidotomy, thalamotomy, transplantation and deep brain stimulation). 10. Subjects with severe disabling dyskinesias. 11. Subjects with hearing, visual or motor impairments that prevent them from using the pump or reacting effectively to errors