Autologous Dendritic Cell Vaccine in Patients With Soft Tissue Sarcoma

Inclusion Criteria: * age of 18 or older * ECOG performance score 0 or 1 * Histologically proven soft tissue sarcoma * Unresectable or metastatic soft tissue sarcoma * Ability to give written informed consent * Objective measured and measurable tumor lesions * The failure of standard therapy * Adequate amount of material for genetic research * No active or chronic infection with HIV, Hepatitis B or Hepatitis C * Men/Women of childbearing potential must use adequate contraception * Hematology, liver function and renal function lab tests within required parameters Exclusion Criteria: * Untreated or uncontrolled brain metastases. * History of other active malignancy within last 2 years, except adequately treated other soft tissue sarcoma. * Autoimmune disease (vitiligo is not a basis for exclusion). * Serious uncontrolled medical disorder or active infection that would impede treatment. * Underlying medical or psychiatric condition that would cause administration vaccine * Any non-oncology vaccine therapy up to 1 month before or after any dose of vaccine * Concomitant therapy with IL-2, interferon, other non-study immunotherapy, or cytotoxic chemotherapy; immune-suppressive agents within 30 days of registration; other investigational therapies; chronic use of systemic corticosteroids (however, a low stable dose steroid for mild brain edema or adrenal insufficiency is allowed; topical and inhaled standard dose corticosteroids are allowed). * Dementia or significantly altered mental status that would prohibit understanding or rendering of informed consent and compliance with protocol requirements. * Pregnant or breastfeeding women. * Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g. infectious) illness.