To determine the efficacy of prophylaxis with 0.12% chlorhexidine gluconate compared with placebo to prevent ventilator associated pneumonia in children admitted to a pediatric critical care unit.
Randomised controlled trial to determine the efficacy of 0.12% chlorhexidine gluconate compared with placebo to prevent ventilator associated pneumonia in children admitted to a pediatric critical care unit.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
70
Bexident® (0.12% chlorhexidine solution)
7.4% alcohol, glycerine, normal saline solution, applied topically, every 8 hrs.
Sinaloa Pediatric Hospital
Culiacán, Sinaloa, Mexico
RECRUITINGIncidence of ventilator associated pneumonia
Time frame: Participants will be followed for the duration of intensive care unit stay, an expected average of 2 weeks
Mortality
Time frame: Participants will be followed for the duration of intensive care unit stay, an expected average of 2 weeks
Days of mechanical ventilation
Time frame: From date of randomization until the date of death or date of extubation, whichever comes first, an expected average of 2 weeks
Length of stay
Time frame: From date of randomization until the date of death or date of discharge from the intensive care unit, an expected average of 2 weeks
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