Effects of Exercise Training on Mechanoreflex and Metaboreflex Control in Heart Failure Patients

University of Sao Paulo General Hospital34 enrolled

Overview

The investigators hypothesize that exercise training would improve the mechanoreflex and metaboreflex control in heart failure patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Heart Failure

Interventions

Aerobic Exercise TrainingOTHER

Eligibility

Sex: ALLMin age: 30 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with systolic heart failure; * New York Heart Association (NYHA) class II-III; * Left ventricular ejection fraction less than 40%; * Peak Oxygen Consumption less than 20 ml/Kg/min; * Stable Clinical Status. Exclusion Criteria: * Chronic Obstructive Pulmonary Disease; * Neuromuscular Diseases; * Orthopedic Diseases; * Neurologic Diseases; * Neoplastic Diseases; * Recent myocardial infarction or cardiac surgery (less than 6 months); * Unstable angina pectoris; * Atrial Fibrillation; * Pacemakers users; * Changing medication or hospital admission.

Locations (1)

Heart Institute (InCor), University of Sao Paulo Medical School

São Paulo, Brazil

Outcomes

Primary Outcomes

Autonomic Control

Mechanoreceptors were activated by passive exercise and metaboreceptors by post-exercise circulatory arrest

Time frame: 4 months

Muscular Evaluation

Muscular evaluation will be done by muscle gene expression

Time frame: 4 months

Secondary Outcomes

Functional Capacity

Functional Capacity will be determined by cardiopulmonary exercise testing

Time frame: 4 months

Muscle Blood Flow

Forearm blood flow will be assessed by venous occlusion plethysmography

Time frame: 4 months

Blood Pressure

Blood pressure will be monitored non-invasively

Time frame: 4 months

Data from ClinicalTrials.gov

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