Impact of Dairy Products on Postprandial Inflammation

Agroscope Liebefeld-Posieux Research Station ALP21 enrolled

Overview

The study will quantitatively evaluate the systemic, postprandial inflammatory and metabolic response to the ingestion of three different meals in obese subjects. The administered meals will differ in the proportion of dairy products. Postprandial response will be monitored during 6 hours after meal consumption.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Inflammation Obesity Nutritional Intervention

Interventions

consumption of test meal based on dairy productsOTHER

consumption of high fat test meal without dairy productsOTHER

consumption of high fat test meal with dairy productsOTHER

Eligibility

Sex: MALEMin age: 25 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * male * BMI ≥ 20 kg/m2 * age 25-55 y * informed consent Exclusion Criteria: * Physiological or psychological diseases * Allergies to food or intolerance to high-fat meal * Vegetarians * Chronic intake of drugs * Smokers * Diabetes mellitus Type I and II * Debilitating kidney diseases * Debilitating liver diseases * Clinically established coronary heart diseases * Ingestion of vitamins or dietary supplements during the course of the study

Locations (1)

University Hospital, Inselspital Berne

Bern, Canton of Bern, Switzerland

Outcomes

Primary Outcomes

Inflammation markers in blood plasma (IL-6, TNF-alpha)

Time frame: 0,6h

Secondary Outcomes

Biomarkers in blood (serum insulin, plasma glucose, GLP-1, lipids)

Time frame: 0,1,2,4,6h

Endotoxin in blood serum

Time frame: 0,6h

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.