Particle steroid drug such as triamcinolone has been used widely for epidural steroid injection (ESI) treatment in Korea. However, Korea FDA recently prohibit ESI using triamcinolone, following the regulation of US FDA. Therefore, dexamethasone and betamethasone become only candidate drugs for ESI in Korea and the investigators are curious about the effectiveness and safety of both drugs due to limitation of information about comparison of two drugs in previous literature. So, this study aims to compare the effectiveness and safety of both drugs and our hypothesis is that there is no difference of the effectiveness between dexamethasone and betamethasone at 2 weeks after ESI.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
600
epidural steroid injection using dexamethasone
epidural steroid injection using betamethasone
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
the proportion of patients with pain improvement
the proportion of patients with significant pain improvement at 2 week after epidural steroid injection, with the patients' subjective satisfaction scale of "much improved" or "no pain"
Time frame: baseline and 2 weeks
incidence of adverse events
incidence of adverse event during 12 weeks after epidural steroid injection
Time frame: during 12 weeks after epidural steroid injection
pain relief
decrease of visual analog scale (VAS) for pain at 2 week time point after epidural steroid injection, compared to baseline at 0 week
Time frame: baseline and 2 weeks
disability improvement
decrease of disability index (Oswestry disability index or Neck disability index) for pain at 2 week time point after epidural steroid injection, compared to baseline at 0 week
Time frame: baseline and 2 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.