Appropriate Dose of Neostigmine for Reversal of Rocuronium and Cisatracurium

Seoul National University Hospital112 enrolled

Overview

This study aims to find appropriate dose of neostigmine which is possible to reverse rocuronium or cisatracurium till train of four (TOF) 0.9 within 10 minutes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

112

Conditions

Observation of Neuromuscular Block

Interventions

Injection of neostigmineDRUG

At induction, we will inject rocuronium 0.6 mg/kg for rocuronium arms and cisatracurium 0.15 mg/kg for cisatracurium arms. During surgical procedure, we will monitor train of four(TOF)using nerve stimulator. When TOF ratio recover to 0.5, normal saline 5 ml will be injected in placebo arms. And neostigmine 10, 20, or 40 ㎍/kg will injected in each arms.

Eligibility

Sex: ALLMin age: 19 YearsMax age: 69 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologist Physical status classification 1 or 2 elective surgery under general anesthesia Exclusion Criteria: * BMI \>25 or \< 20 kg/m2 * Patients taking intercurrent medication * Glutamic Oxalacetate Transaminase or Glutamic Pyruvate Transaminase \> 40 IU/L, Cr \> 1.4 mg/dl

Locations (1)

Eunsu Choi

Seongnam-si, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

time to reverse from light muscle relaxation

Primary outcome of this study is how long it takes time to reverse from TOF ratio 0.5 to 1.0 after injection of different doses of neostigmine at the TOF 0.5

Time frame: time from TOF 0.5 to TOF 1.0 after injection of different doses of neostigmine

Secondary Outcomes

time to reverse from TOF ratio 0.5 to 0.9

Secondary outcome of this study is how long it takes time to reverse from TOF ratio 0.5 to 0.9 after injection of different doses of neostigmine at the TOF 0.5

Time frame: time from TOF 0.5 to TOF 0.9 after injection of different doses of neostigmine

Data from ClinicalTrials.gov

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