The Effects of Dexmedetomidine on Postoperative Renal Function in Valvular Heart Surgery

Yonsei University200 enrolled

Overview

The purpose of study is to compare the incidence of acute kidney injury in patients receiving perioperative dexmedetomidine or placebo undergoing valvular heart surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

200

Conditions

Acute Kidney Injury

Interventions

dexmedetomidineDRUG

0.4 mcg/kg/h, IV, The infusion of study drug is started after anesthesia induction and continued until 24 hours after surgery

SalineDRUG

0.4 mcg/kg/h, IV

Eligibility

Sex: ALLMin age: 20 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients over the age of 20 scheduled for valvular heart surgery Exclusion Criteria: * Left ventricular-ejection fraction \< 30% * Preexisting congestive heart failure * Severe coronary artery disease * Hemodynamically unstable arrhythmia * Cardiogenic shock during perioperative period * Ventricular assist device * Severe renal dysfunction (eGFR \< 15ml/min per 1.73m2)

Locations (1)

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

Comparison of postoperative renal function in patients with or without dexmedetomidine undergoing valvular heart surgery:

BUN/Creatinine, cystatin C, eGFR, urine output Incidence of acute kidney injury (based on the AKIN criteria)

Time frame: 24 hours after surgery.

Central Contacts

Jong Wook Song, MD

CONTACT

82-2-2228-2420 SJW72331@yuhs.ac

Data from ClinicalTrials.gov

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