Efficacy of different protocols of transcranial magnetic stimulation for the treatment of tinnitus
Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex has an add-on effect for primary auditory cortex rTMS in improving tinnitus-related distress. The investigators aimed to investigate whether rTMS of the dorsolateral prefrontal cortex and primary auditory cortex are capable of reducing tinnitus loudness.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
80
repetitive transcranial magnetic stimulation (Figured 8-Coil Cool-B65): 1000 stimuli of 1Hz rTMS over the left dorsolateral prefrontal cortex (110% motor threshold) followed by 2000 stimuli of 1 Hz rTMS over the left primary auditory cortex (110% motor threshold), each consisting of 4 days of rTMS treatment. (20 subjects).
repetitive transcranial magnetic stimulation (Figured 8-Coil MCF-B65): 3000 stimuli of 1 Hz rTMS over the left temporal cortex (110% motor threshold), each consisting of 4 days of rTMS treatment. (20 subjects)
repetitive transcranial magnetic stimulation (Figured 8-Coil MCF-B65): 3000 stimuli of 1 Hz rTMS over the left dorsolateral prefrontal cortex (110% motor threshold) each consisting of 4 days of rTMS treatment. (20 subjects)
Seoul National University Hospital
Seoul, South Korea
Change of tinnitus severity as measured by the Tinnitus Handicap Inventory (THI)
Time frame: Change from Baseline inTinnitus Handicap Inventory at 3 months
Beck's Depression Inventory (BDI)
Time frame: Baseline, before and after each intervention, 1, 2 and 3 months after the first intervention
State-Trait Anxiety Inventory (STAI)
Time frame: Baseline, before and after each intervention, 1, 2 and 3 months after the first intervention
Pittsburgh Sleep Quality Index (PSQI)
Time frame: Baseline, before and after each intervention, 1, 2 and 3 months after the first intervention
visual analogue scale (VAS)
Time frame: Baseline, day 7, day 14, 1, 2 and 3 months after the first intervention
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Sham rTMS, applied with the same combination of parameters as active rTMS, except for the number of stimulations per session. (20 subjects)