Auditory Verbal Hallucinations in Schizophrenia

University Hospital, Grenoble40 enrolled

Overview

Auditory verbal hallucinations (AVHs) are speech perceptions in the absence of a relevant external stimulation. Some accounts of AVHs claim that a deficit in inner speech monitoring would cause the verbal thoughts of the patient to be perceived as external voices resulting in AVHs. In order to examine whether AVHs correspond to self-generated inner speech, the present study aims at collecting speech muscle activity during covert AVHs (without articulation), overt speech and rest. Surface electromyography (sEMG) is used on schizophrenia patients and control subjects to detect any speech muscle activity during AVH.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Schizophrenia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Healthy controls: * must be more than 18 years and less than 60 years old * pre-inclusion medical examination * must have signed consent form * must be able to read stimuli on a screen Schizophrenia patients: * must be more than 18 years and less than 60 years old * pre-inclusion medical examination * must have signed consent form * must be able to read stimuli on a screen * diagnosed with a schizophrenia disorder according to DSM-IV TR (diagnostic and statistical of mental disorders) (PANSS item P3 greater than 4) * prior evaluation of the secondary effects of any medication via Barnes and AIMS scales * affiliated with the French social security * if under guardianship, must have additional consent form signed by guardian Exclusion Criteria: Healthy controls: * if aged less than 18 years or more than 60 years * diagnosed with any psychiatric disorder * with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.) * with auditory impairment * pregnant, parturient, breast-feeding Schizophrenia patients: * if aged less than 18 years or more than 60 years * significant secondary effects of antipsychotic medication, measured with the Barnes and AIMS scales * with a neurodegenerative disease * with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.) * with auditory impairment * pregnant, parturient, breast-feeding

Locations (1)

University Hospital of Grenoble

Grenoble, France

Outcomes

Primary Outcomes

Labial EMG activity during auditory verbal hallucination

Time frame: up to 3 years

Data from ClinicalTrials.gov

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