Retaining Cognition While Avoiding Late-Life Depression

University of Pittsburgh94 enrolled

Overview

This study will adapt Problem Solving Therapy (PST) for individuals with mild cognitive impairment (MCI) as an intervention for preventing major depression (DEP). PST will be modified so as to be provided to both MCI probands as well as their support person. The primary aim is to examine the effectiveness of PST in individuals with MCI and the support person, at preventing DEP over 12 mos. in MCI probands. We also will examine the effect of exercise on preventing depression.

The Recall Study (Retaining Cognition while Avoiding Late-Life Depression) is a study for adults 60 and older who have noticed mild memory changes in themselves or a loved one. Mild memory changes may feel stressful and therefore increase an individual's risk of developing depression. This research project will test whether Problem Solving Therapy (PST) is successful in preventing major depression for those living with mild cognitive impairments. We will also examine the effect of modest exercise on mood. You will participate in 8 to 12 PST sessions over 16 weeks. All treatments are provided at no cost and there is compensation for participation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Mild Cognitive Impairment

Interventions

Problem Solving TherapyBEHAVIORAL

6-12 sessions of Problem Solving Therapy (both members of dyad)

Problem Solving Therapy + ExerciseBEHAVIORAL

6-12 sessions of Problem Solving Therapy + Exercise (both members of dyad)

Enhanced Usual CareOTHER

Staff will document and monitor all mental health treatment (e.g., medications that participant may be taking) and psychotherapy (e.g. counseling or social services).

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

MCI participant Inclusion Criteria: 1. =\> age 60 2. Modified Mini Mental State (3MS) =\> 80 3. MCI diagnosis 4. Adequate physical and sensory function to undergo NP assessment 5. PHQ-9 score 1-9, with at least one of the cardinal symptoms of depression (low mood or anhedonia) endorsed. MCI participant Exclusion Criteria: 1. Major Depressive Episode or anxiety disorder within the past 1 year 2. Currently taking an anti-depressant 3. History of Bipolar Disorder or Schizophrenia 4. Drug or alcohol use disorder within 12 months 5. Currently taking anti-anxiety med \>4x/week for the past 4 weeks Support person Inclusion Criteria: 1. =\> age 18 2. Modified Mini Mental State (3MS) =\> 80 3. Normal Cognitive Function 4. Adequate physical and sensory function to undergo NP assessment 5. PHQ-9 score 1-9, with at least one of the cardinal symptoms of depression (low mood or anhedonia) endorsed. Support person Exclusion Criteria: 1. Major Depressive Episode or anxiety disorder within the past 1 year 2. Currently taking an anti-depressant 3. History of Bipolar Disorder or Schizophrenia 4. Drug or alcohol use disorder within 12 months 5. Currently taking anti-anxiety med \>4x/week for the past 4 weeks

Locations (2)

UPMC Late-Life Evaluation and Treatment Center

Pittsburgh, Pennsylvania, United States

UPMC Western Psychiatric Institute and Clinic

Pittsburgh, Pennsylvania, United States

Outcomes

Primary Outcomes

Incidence of depression or anxiety disorders

PHQ9, prime-MD SCID, GAD7

Time frame: 15 months

Secondary Outcomes

Change in cognitive function measured by RBANS and DKEFS

RBANS, DKEFS, 3MS, PASS, CAMCI, CIRS-G, RAND-12, LLFDI, SPPB, PSQI, NRS, ISEL, PROMIS, Cornell Services Index, P-GIC, ZARIT, DAS

Time frame: 15 months

Data from ClinicalTrials.gov

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