Renal Denervation Therapy for Resistant Hypertension in Type 2 Diabetes Mellitus

Inclusion Criteria: * Age ranges from 18 to 70 years inclusive * Essential hypertension * Office Systolic BP (SBP) ≥ 150 mmHg or Diastolic BP (DBP) ≥ 90mmHg * 3 or more anti-hypertensive medications of different classes, including a diuretic, or documented intolerance to multiple medications * Type 2 Diabetes Mellitus on oral hypoglycaemic agent (OHA) * 2 functional kidneys; eGFR ≥ 45 mL/min/1.73m² (MDRD formula) * Suitable renal anatomy compatible with the endovascular denervation procedure Exclusion Criteria: * Individual has renal artery anatomy that is ineligible for treatment including: * Patients with secondary hypertension * Myocardial infarction, unstable angina pectoris, cerebrovascular accident within 6 months * Patient with type 1 diabetes mellitus * Patient on insulin due to oral drug failure * Renovascular abnormalities (including severe renal artery stenosis, previous renal stenting or angioplasty, or known dual renal arteries) * Pregnancy * Patient with any implantable device incompatible with radiofrequency energy delivery * Hemodynamically significant valvular heart disease for which reduction of BP would be considered hazardous * Any serious medical condition, which in the opinion of the investigator, may limit the life expectancy of patients or adversely