A Control Study to Evaluate The Efficacy And Safety of Ozone-therapy in Chronic Hepatitis B

Inclusion Criteria: * Male or female； * HBsAg positive for over 6 months； * ALT over 2×ULN, TBIL less than 80 µmol/L. Exclusion Criteria: * Patient has a history of hemorrhagic or hemolysis disease; * Patient has any history of clinical signs/symptoms of hepatic decompensation or serious metabolic hepatic disease; * Patient is co-infected with HIV or HCV; * Patient is treated with anti-virus drug like interferon or nucleoside analogue in recent 6 months; * Patient is treated with immunosuppressive agent for long time, including patient has a history of organ transplantation; * Pregnancy; * Current alcohol or drug abuse; * Difficulty to draw blood through veins; * Patient has a history of carcinoma, or finding suggestive of possible hepatocellular carcinoma (HCC), or AFP over than 100ng/ml; * Patient has a history of any severe physical disease such as cardio-vascular, kidney events, hyperthyroidism or serious electrolyte disturbance; * Patient is enrolled in any other clinical trials.