Pilot Pharmacokinetic Study of Investigational Sublingual Nicotine Tablet Versus COMMIT Nicotine Lozenge

Inclusion Criteria: * Subjects have to be 18-45 years old * Subjects must provide written informed consent prior to any study related procedures being performed. * Subjects must have a willingness and ability to comply with the protocol requirements. * Subjects must be in good health and free from any clinically significant pathology (gastrointestinal tract, hepatic, renal, cardiovascular, central nervous system diseases) * Subjects must have body mass index not to exceed 35 * Female subjects of childbearing potential, in addition to having a negative urine pregnancy test, must be willing to use a form of birth control during the study. The hormonal contraceptives should be avoided within 2 month prior to study entry. * Subjects must consume more than 15 cigarettes daily and smoke their first cigarette within 30 minutes of awaking from sleeping. * A Fagerstrom Smoking index greater than 4 Exclusion Criteria: * Subjects that have used other nicotine delivery system such as nicotine lozenge, nicotine patch, nicotine inhaler, or nicotine nasal spray etc. within 30 days of study entry. * Subjects who have smoked any substance other than tobacco within 30 days of study entry. * Subjects that have used other smoking cessation aids (including bupropion, herbals, counseling, etc.) within 30 days of study entry. * Subjects who have currently involved in another clinical trial or have used any investigational drug within 3 month of study entry. * Subject who is pregnant or lactating, or planned to became pregnant within 6 months. * Subjects who have diagnosed heart disease or are being treated with medication or had an irregular heartbeat or have had a heart attack. * Subject with diagnosed stomach ulcers. * Subjects who have taking insulin for diabetes. * Subjects with high blood pressure not controlled by medication or a blood pressure greater than 150 mmHg systolic or 90 mmHg diastolic * Subjects who are unable to fulfill study requirements in relation to conforming to the visit schedule. * Subjects who have severe allergic history * Subjects who have known intolerance to medication * Subjects who have diagnosed chronic diseases of cardiovascular, pulmonary, neuro-endocrine systems, gastrointestinal, hepatic, renal, and blood diseases * Subjects who had surgical operations on gastrointestinal tract with the exception of appendectomy * Subjects who had acute infectious diseases within the last 4 weeks prior to the study entry; * Subjects who donated 450 mL and more of his/her blood or blood plasma within the last 2 month prior to the study entry * Subjects who are taking more than 10 units of alcohol per week or have a history of alcohol and drug abuse