Study of Lumacaftor in Combination With Ivacaftor in Subjects With Moderate Hepatic Impairment and Healthy Subjects

Inclusion Criteria: Group A: Subjects with Moderate Hepatic Impairment * Male and female 18 to 65 years of age (inclusive) * Satisfy the criteria for moderate hepatic impairment defined as a Child Pugh total score of 7 to 9 (Child Pugh Class B) at the Screening Visit * Willing and able to comply with schedule visits, treatment, laboratory tests, and contraceptive guidelines. Group B: Healthy subjects * Male and female 18 to 65 years of age (inclusive) * Healthy subjects with no clinically relevant abnormalities identified by a detailed medical history, complete physical examination, including blood pressure and pulse rate measurement, standard 12-lead ECG, and clinical laboratory tests * Willing and able to comply with schedule visits, treatment, laboratory tests, contraceptive guidelines and other study procedures Exclusion Criteria: Group A: Subjects with Moderate Hepatic Impairment * History of any illness that, in the opinion of the investigator, might confound the results of the study or pose an additional risk in administering study drug(s) to the subject * Have fluctuating or rapidly deteriorating hepatic function by history or as indicated by significant variations in or worsening of clinical and/or laboratory signs of hepatic impairment within 6 months before the Screening Visit * Other causes of hepatic impairment not related to parenchymal disorder and/or disease of the liver * Severe hepatic encephalopathy * Type 1 diabetes mellitus or evidence of poorly controlled type 2 diabetes * Hepatocellular carcinoma, HIV, hepatitis B/C * Significant renal dysfunction * Solid organ or bone marrow transplantation * History of regular alcohol consumption, drug abuse or regular smoking Group B: Healthy subjects * History of any illness that, in the opinion of the investigator, might confound the results of the study or pose an additional risk in administering study drug(s) to the subject * History of regular alcohol consumption, drug abuse or regular smoking