CT in Diagnosing Patients With Lung Cancer

Virginia Commonwealth University10 enrolled

Overview

This clinical trial studies computed tomography (CT) in diagnosing patients with lung cancer. Diagnostic procedures, such as CT, may help find and diagnose lung cancer.

PRIMARY OBJECTIVES: I. Conduct a prospective clinical imaging study to quantify the amount of inter- and intra-physician contouring variability on four dimensional (4D) CT, active breathing control (ABC) CT, free breathing CT, and free breathing and ABC cone beam (CB)CT. II. Quantify the magnitude and distribution of target and organ at risk volume variations between the different imaging modalities. III. Determine dosimetric changes related to contouring variations for tumor and normal tissue. OUTLINE: Patients undergo conventional free breathing CT, 4D CT, ABC CT, ABC CBCT, and free breathing CBCT before undergoing radiation therapy.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Lung Cancer

Interventions

computed tomographyPROCEDURE

Undergo conventional free breathing CT

4-dimensional computed tomographyPROCEDURE

Undergo 4D CT

computed tomographyPROCEDURE

Undergo ABC CT

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Measurable disease on CT scan * Patients with lung cancer visible on CT who are scheduled to receive external beam radiation treatment will be eligible for this study * Patients must be able to perform ABC procedures Exclusion Criteria: * Patients requiring continuous supplemental oxygen due to the requirement of spirometry during all imaging studies * No vulnerable populations will be enrolled (prisoners, children, pregnant females or institutionalized individuals) * Women of childbearing potential will undergo a pregnancy test

Locations (1)

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, United States

Outcomes

Primary Outcomes

Amount of inter- and intra-physician contouring variability on 4D CT, ABC CT, free breathing CT, and free breathing and ABC CBCT

A two sided t-test with 5% level of significance will be used.

Time frame: up to 1 week

Secondary Outcomes

Magnitude and distribution of target and organ at risk volume variations between the different imaging modalities

A two sided t-test with 5% level of significance will be used.

Time frame: up to 1 week

Dosimetric changes related to contouring variations for tumor and normal tissue

A two sided t-test with 5% level of significance will be used.

Time frame: up to 1 week

Data from ClinicalTrials.gov

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