Risk of Uncomplicated Peptic Ulcer in the General Population

AstraZeneca4,000 enrolled

Overview

The analyses are conducted in a previous population-based cohort study using The Health Improvement Network database in the UK (Cai et al 2009).The aims of the post hoc analyses are: To estimate the relative risk of uncomplicated symptomatic peptic ulcer (UPU) associated with use of low dose aspirin (ASA) and other anti-inflammatory drugs (NSAIDs, steroids) in the general population To estimate the dose-response and duration-response associated with use of these drugs To estimate the relative risk of UPU associated with naive/non-naive use of low dose ASA in the general population To evaluate the effect of proton pump inhibitors (PPI) (alone or in combination with anti-inflammatory drugs) on the occurrence of UPU in the general population To investigate the management of low dose ASA/oral antiplatelets after UPU

Risk of uncomplicated peptic ulcer in the general population

Study Type

OBSERVATIONAL

Enrollment

4,000

Conditions

Peptic Ulcer [Iowa Type (107680.0010)]

Interventions

Risk of symptomatic peptic ulcerDRUG

Eligibility

Sex: ALLMin age: 40 YearsMax age: 84 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Patients aged 40-84 years in 1997-2005 ( see study population description) Exclusion Criteria: \- Patients aged below age 40 and 85 years and above ( see study population description)

Outcomes

Primary Outcomes

Relative risk (ratio) of uncomplicated peptic ulcer (UPU) associated with low dose ASA, other antiinflammatory drugs and other common drugs for chronic diseases(paracetamol, SSRI, tricyclic antidepressants, anticoagulants, acid suppressing drugs)

Relative risk (ratio) of UPU associated with current use of the different types of drugs versus non-use.

Time frame: From Januar 1 1997 till December 31 2005, an expected average of 4 years.

Management of aspirin after uncomplicated peptic ulcer (UPU).

Time frame: From January 1, 1997 till december 31, 2005, an average of 4 years