Diastolic Dysfunction in Patients With Type 2 Diabetes Mellitus

Inclusion Criteria: 1. Diabetes mellitus Type 2 2. Age \> 50 years 3. HbA1c \> 7% 4. Left ventricular diastolic dysfunction determined by echocardiography as average E/é ≥13 or average E/é≥8 and LA volume ≥34ml/m2 5. Stable anti-diabetic medication for the last 6 weeks which should include a maximal tolerated dose of metformin (unless contraindication or intolerance to metformin does exist). 6. Indication to increase anti-diabetic medication as judged by the investigator 7. Written informed consent prior to study participation Exclusion Criteria: 1. Diabetes mellitus type 1 2. Echocardiography: * decreased left ventricular systolic function, ejection fraction (EF) \<45% * regional wall motion abnormalities * hypertrophic cardiomyopathy (septum \>15mm) * severe valvular dysfunction 3. Uncontrolled hypertension 4. Atrial fibrillation 5. Obstructive sleep apnea syndrome 6. Use of DPP-4 Inhibitor (Dipeptidyl-peptidase IV Inhibitor), GLP 1 agonists, Thiazolindinedione 7. Kidney disease CKD 4 and more (GFR \< 30 ml/min/1.73) 8. Liver disease (ALT or AST \> 3 times the upper limit of norm) or known liver cirrhosis 9. Active malignant disease 10. HbA1c \> 8.5% 11. Recent (\<3 months) clinically significant coronary or cerebral vascular event 12. Pregnant females as determined by positive \[serum or urine\] hCG test at Screening or prior to dosing. Participants of child-bearing age should use adequate contraception as defined in the study protocol. 13. Lactating females 14. The subject has a history of any other illness, which, in the opinion of the Investigator, might pose an unacceptable risk by administering study medication. 15. The subject received an investigational drug within 30 days prior to inclusion into this study 16. The subject has any current or past medical condition and/or required medication to treat a condition that could affect the evaluation of the study 17. The subject is unwilling or unable to follow the procedures outlined in the protocol 18. The subject is mentally or legally incapacitated