Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men

University of Toronto30 enrolled

Overview

The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

The relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake is undefined. This study is examining the effects of three modulators of substrate oxidation (RER), a glucose preload, exercise and age food intake regulation and net energy balance in normal-weight boys (9-12 y) and men (20-30 y). Subjects (15 boys, 15 men) were measured in random order with treatments of beverages of either water or glucose followed by either moderate exercise or rest for 40 min. Measures included RER via indirect calorimetry, energy expenditure, subjective appetite, food intake measured at an ad libitum pizza meal and net energy balance as the sum of the calories of the glucose preload + calories from the pizza lunch minus energy expended at exercise or rest.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Food Intake Regulation Substrate Oxidation

Interventions

Glucose Preload and Exercise InterventionOTHER

A glucose preload and exercise were administered to examine the modulate substrate oxidation

Eligibility

Sex: MALEMin age: 9 YearsMax age: 29 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Born at full term * Men Age:20-29 years/BMI: 20-25 * Boys Age 9-11/BMI percentile: 15th to 85th: Exclusion Criteria: * Smokers * Dieters * Individuals with lactose intolerance, allergies to milk and dairy products * Individuals with gastrointestinal problems * Individuals with diabetes or other metabolic diseases * Individuals scoring ≥ 11 on an Eating Habit Questionnaire

Locations (1)

Department of Nutritional Sciences, University of Toronto

Toronto, Ontario, Canada

Outcomes

Primary Outcomes

Food Intake

Energy intake from the ad libitum the pizza meal at 60 min was calculated based on the weight consumed and the compositional information provided by the manufacturer.

Time frame: 60 - 90 min in the study

Secondary Outcomes

Net Energy Balance

Will be calculated from the energy consumed by the glucose preload and the pizza meal minus energy expended at the exercise.

Time frame: 0-90 min in the study

Data from ClinicalTrials.gov

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