Extent of use of generics immunosuppressive drugs in clinical practice after lung transplantation
Solid organ transplant recipients are treated with immunosuppressive drugs to prevent rejection of their grafts. The most frequently important maintenance immunosuppressive drugs in Europe are calcineurin inhibitors. For a number of these compounds drug patents have expired in recent years and generic formulations have entered the market. There is considerable debate regarding the efficacy and safety of generic drug substitution in solid organ recipients.
Study Type
OBSERVATIONAL
Enrollment
600
Hannover Medical School
Hanover, Lower Saxony, Germany
RECRUITINGFrequency of use of generic immunosuppressive drugs
Time frame: baseline
Calcineurin inhibitor through levels
Frequency of calcineurin inhibitor through levels in target range between generic and original immunosuppressive drugs during last 6 months
Time frame: baseline, retrospective 6 months
Dose of calcineurin inhibitors
Dose of calcineurin inhibitors between generic and original immunosuppressive drugs at questionnaire
Time frame: baseline
Therapy adherence
Therapy adherence between generic and original immunosuppressive drugs. Adherence will be measured by a 5 item Likert scale covering self-monitoring, generla health perception, contacts, nutrition/exercise compliance and adherence to immunosuppression.
Time frame: baseline
Satisfaction with immunosuppression
Satisfaction with immunosuppression between generic and original immunosuppressive drugs will be measured by a 5-point Likert scale.
Time frame: baseline
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