Anti-nucleosome B Lymphocytes in Lupus

University Hospital, Strasbourg, France4 enrolled

Overview

Lupus disease is characterized by the production of pathogenic autoantibodies, which participate in end-organ damages. The phenotype of B cells producing the pathogenic autoantibodies in lupus patients is today unknown. Antinucleosome antibodies are characteristic of lupus disease.This project proposes to detect antinucleosome B cells in lupus patients and to analyse their phenotype and their frequency.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Systemic Lupus Erythematosus With or Without Clinical Activity

Interventions

Venous blood samplingOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria for SLE patients: SLE patient : diagnostic based on ACR criteria * SLE patient producing seric anti-nucleosome antibodies (ELISA) * SLEDAI-2K activity score : inferior to 5 for quiescent patients, superior to 8 since at least 2 months for active patients Exclusion criteria for SLE patients: \-- Other autoimmune diseases than SLE- Induced lupus * Treatment with corticosteroids \>10mg/d (prednisone) for quiescent patients * Treatment with corticosteroids \>20mg/d (prednisone) for active patients * Oral immunosuppressive treatment during the last 6 months (methotrexate, azathioprine, ciclosporine, mycophénolate mofétil) for all patients, treatment during the last year with cyclophosphamide or monoclonal antibodies (rituximab, belimumab) for pour quiescent patients * Disease which can modify B and T lymphocyte functions: primary immune deficiencies, evolutive infections, chronic viral infection (VIH in particular), chemotherapy or neoplasm antecedent

Locations (1)

Les Hôpitaux Universitaires de Strasbourg

Strasbourg, Bas Rhin, France

Outcomes

Primary Outcomes

all cause mortality

Time frame: 1 year

Data from ClinicalTrials.gov

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