Safety and Immunogenicity Study in Young Adults the Meningococcal Serogroup C Vaccine Produced by Bio-Manguinhos

Inclusion Criteria: * Both sexes. * Age between 18 and 50. * Available for follow-up during the period of the study * Willing to provide their name, address, telephone number and other information by each they can be contact for the study learn if necessary (eg in case of lack the scheduled visit). * Willing to strictly follow the study protocol. * Ability to understand and signing the consent form. * Understanding the impossibility to participate in another clinical trial during the time which is participating in the study. * Intellectual level that allows filling in the forms for registration of symptoms at home. * Acceptance for serological testing for human immunodeficiency virus (HIV), Hepatitis B virus (HBV) and Hepatitis C virus (HCV). * Be in good health, with no significant medical history. * Physical examination screening without significant clinical changes. * Screening laboratory tests within normal limits established the laboratory or abnormal values smaller than 1 degree. * Additional criterion for females: Negative pregnancy test before application of the vaccine dose, for women of childbearing age. Exclusion Criteria: \- Pregnant or breast-feeding. Personal history of: * Meningitis of any kind. * Serious adverse reaction to any vaccination, such as difficulty breathing, angioedema and anaphylaxis. * Severe adverse reaction related to prior immunization with tetanus and / or diphtheria vaccines alone or in combination vaccines. * Vaccination with tetanus and diphtheria vaccines alone or in combinations vaccine in the last two years. * Use of allergy shots antigens within 14 days or less prior to vaccination. * Immunoglobulin in the last 12 months before vaccination. * Use of blood products in the last 12 months before vaccination. * Use of any vaccine 30 days before vaccination. * Chronic use of any medication except homeopathic and trivial as Nasal saline and vitamins. * Previous use of cytotoxic or immunosuppressive medication. Are acceptable individuals who have made use of this type of immunosuppressive medication in doses not more than six months, such as nasal steroids for allergic rhinitis or dermatitis to topical corticosteroid uncomplicated. * Use of any investigational medication over a period of 1 year prior to vaccination. * Unstable asthma or has required urgent care, hospitalization or intubation in the last two years, or requiring use of oral or intravenous corticosteroids. * Severe anaphylaxis or angioedema. * Neurological, cardiovascular, respiratory, hepatic, renal, hematologic, rheumatologic or autoimmune clinically significant (diseases that have led to hospitalization or prolonged treatment). * Coagulopathy diagnosed by a medical report or capillary fragility (eg bruising or bleeding without justifiable cause). * Seizures, except that they have been fever, before 2 years of age. * Psychiatric illness that impairs adherence to protocol, such as psychoses, neuroses obsessive-compulsive disorder, bipolar disorder being treated, diseases requiring lithium treatment and suicidal ideation in the last five years prior to enrollment. * Active malignancy (eg any type of cancer) or treated to recourse during the study. * Sickle cell anemia. * Asplenia (or absence of spleen removal of same). * HIV positive in the screening test or history of any immunosuppressive disease. * Positive serology for hepatitis C screening test. * HBsAg positive in the screening test. * Alcoholism (CAGE criterion), used for detection of abusive drinkers and alcoholics, validated in our population with a sensitivity of 88% and specificity of 83% if two or more responses among four possible, are affirmative. * Use / abuse of drugs.