Preeclampsia is one of the three leading causes of maternal morbidity and mortality all over the world. The use of low dose aspirin has been mentioned in several studies with promising results. The investigators decided to evaluate the use of low dose aspirin, starting between 13 and 16 weeks of pregnancy, based on clinical characteristics only to reduce the incidence of preeclampsia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
476
Saint Thomas Maternity Hospital
Panama City, Panama
Prevention of preeclampsia
The number of cases of preeclampsia that appear in both groups before 34 weeks of pregnancy
Time frame: 6 months
Prevention of preeclampsia at term
The number of cases of preeclampsia that appear in both groups between 37 and 41 weeks of pregnancy.
Time frame: 6 months
Stillbirth
The number of cases of stillbirths that appear in both groups at any given time during pregnancy.
Time frame: 6 months
Neonatal deaths
The number of cases of neonatal deaths that appear in both groups, regardless of the cause.
Time frame: 6 months
Neonatal intensive care unit admissions.
The number of cases that require admittance to the Neonatal Intensive Care Unit in both groups in the first 28 days after birth.
Time frame: 28 days
Abruptio placenta
The number of cases of abruptio placenta that appear in both groups at any given time during pregnancy.
Time frame: 6 months
Fetal Growth Restriction
The number of cases of fetal growth restriction, defined as a fetal weight below the 10th percentile and an abnormal umbilical cord doppler that appear in both groups at any given time during pregnancy.
Time frame: 6 months
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