Study 18F-AV-45-010 is designed to evaluate the cerebral uptake of florbetapir 18F as measured by PET imaging in frontotemporal disorder (FTD) in comparison to cognitively normal volunteers and subjects with Alzheimer's disease (AD).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
34
Subjects received a one-time intravenous (IV) bolus injection of 300 megabecquerels (MBq) florbetapir 18F.
FTD subjects received a one-time IV bolus injection of 185 MBq of 18F-FDG.
Research Site
Manchester, United Kingdom
Qualitative Amyloid Image Assessment
Four readers blinded to all clinical information classified florbetapir Positron Emission Tomography (PET) images as either positive for amyloid or negative for amyloid. The majority read classification is presented as either positive, negative or tied.
Time frame: 50-60 min after injection
Quantitative Amyloid Image Assessment
The effect of diagnostic group on mean total cortical grey matter florbetapir binding relative to cerebellar cortex is presented as standard uptake value ratios (SUVr).
Time frame: 50-60 minutes after injection
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.