Resistance training combined with protein or amino acids supplementation has been shown to be promising for mitigating age-related disabilities and comorbidities. Randomized controlled trials supporting this possibility are still scarce. These series of clinical trials aim to investigate the chronic effects of different strategies of protein and derivatives supplementation in association with resistance training on selected health-related parameters in pre-frail and frail elderly.This is a 16-month, double-blind, randomized, placebo-controlled, parallel-group clinical trial involving a series of investigations. Participants will be divided into nine groups, allowing the assessement of the effects of (1) isolated leucine supplementation; (2) protein source (whey vs. soy); (3) combination of whey protein and creatine; and (4) sexual dimorphism to the response of protein intake plus resistance training (men vs. women). All participants will undergo a supervised, resistance training program.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
200
30 g in total; twice a day (morning and evening)
whey protein combined with creatine (30 g and 6.0 g in total; twice a day, respectively)
7.5 g/d in total; three times per day
30 g in total; twice a day
6.0 g in total; twice a day
University of Sao Paulo
São Paulo, Brazil
lean mass
assessed by Dual-energy X-ray absorptiometry
Time frame: 4 months
muscle function
assessed by a battery of physical tests
Time frame: 4 months
bone mass
assessed by Dual-energy X-ray absorptiometry
Time frame: 4 months
insulin sensitivity
assessed by homeostasis model assessment (HOMA index)
Time frame: 4 months
health related-quality of life
assessed by Short-Form Health Survey (SF-36) (score range: 0 to 100, higher values mean better quality of life)
Time frame: 4 months
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