Intrapartum Oxytocin Administration Affects Primitive Neonatal Reflexes

Puerta de Hierro University Hospital98 enrolled

Overview

The aim of this study was to assess whether administration of oxytocin intrapartum (Oxt) has any effect on Neonatal Primitive Reflexes (RNP) and if dose dependent. The secondary objective is to assess the effects on exclusive breastfeeding at 3 months

Patients and Methods Prospective case-control study performed in a tertiary hospital. Cases: mother-child dyads in which Oxt had been administered during the birth process (n = 53). Controls: mother-child dyads without Oxt (n = 45). The RNP were recorded with a camcorder in biological nurturing position. An observer blinded to the group and the dose of Oxt codified the RNP (reach/not reached). To assess the type of breastfeeding telephone call was made at 3 months old RN.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Bonding Oxytocin Breastfeeding Newborn Perinatal

Interventions

OxytocinDRUG

Comparison of Primitive Newborn Reflexes between those exposed or not to Oxytocin

Eligibility

Sex: ALLMin age: 1 DayMax age: 4 Days

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy singleton term infant delivered vaginally with Apgar at 5 min\> 7; * Expressed desire to administer during pregnancy breastfeeding; * Signed informed consent Exclusion Criteria: * Preterm neonate; * Fetal chromosomal or other abnormalities diagnosed in utero to modify their adaptation to extrauterine environment; * Hospitalization of the mother in ICU; * Hospitalization in the following 48 hours neonate at birth; * Wish to artificial feeding before parturition; * Language difficulties; * Completion of caesarean delivery

Locations (1)

Hospital Universitario Puerta de Hierro-Majadahonda

Madrid, Madrid, Spain

Outcomes

Primary Outcomes

Expression of Neonatal Primitive Reflexes (RNP) are modified by administration of Oxytocin during delivery.

Neonatal Primitive Reflexes studied were: 1) Endogenous: hand to mouth, extension / flexion of fingers, mouth open, tongue extrusion, arm circular motion, circular motion of the leg, flex foot / hand, 2) Antigravity: raise the head, 3) Motors: turn your head, nod, plantar pressure, Babinski, and 4) Rhythmic: suction, jaw movement and swallowing. An observer, blinded to the study group and the dose administered of Oxytocin, valued recordings, analyzing the state of consciousness at the beginning of the recording as Brazelton scale and form RNP dichotomous coding (achieved / not achieved).

Time frame: 72 hours

Secondary Outcomes

Oxytocin intrapartum may have adverse influence on exclusive breastfeeding at 3 months.

To assess the type of feeding (exclusive breastfeeding versus other) at different time points (discharge, one month and three months) a telephone call was conducted at 3 months old of the newborn.

Time frame: 6 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.