Histologic Response to UVA and UVB Exposure During the Use of Sunscreen

Mahidol University2 enrolled

Overview

Anti-inflammatory and anti-oxidant agents have become the important ingredients in sunscreen. However, there is no histologic study about the effects of anti-inflammatory and anti-oxidative properties of sunscreen to prevent premature aging from UVA and UVB.

Premature aging can be prevented by using sunscreen. Currently, anti-inflammatory and anti-oxidant agents have become the important ingredients in sunscreen. However, there is no histologic study about the effects of anti-inflammatory and anti-oxidative properties of sunscreen to prevent premature aging from UVA and UVB.

Study Type

INTERVENTIONAL

Allocation

Masking

TRIPLE

Enrollment

Conditions

Solar Elastosis

Interventions

SunscreenOTHER

Apply sunscreen before and after UVA and UVB irradiation

Eligibility

Sex: FEMALEMin age: 35 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * subjects aged 35-65 years who were scheduled for abdominoplasty * the excised area should be larger than 18x10 cm2 * no skin diseases or lesions on the excised area * no topical treatment on excised area more than 1 month prior to this study Exclusion Criteria: * pregnancy * lactation * have tattoo or striae distensae on abdomen

Locations (1)

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok, Thailand

Outcomes

Primary Outcomes

H&E Staining

Review difference in H\&E staining in tissue biopsy before and after UVA / UVB irradiation

Time frame: 2 Months

Secondary Outcomes

Tyrosinase Staining

Review difference in Tyrosinase staining in tissue biopsy before and after UVA / UVB irradiation to evaluate the effects of pigment darkening after UV exposure

Time frame: 2 Months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.