The objective of this survey is to establish the clinical course of vision loss and recovery in patients with a genetically confirmed diagnosis of Leber Hereditary Optic Neuropathy (LHON). Visual acuity changes over time from onset of symptoms and from visual acuity nadir will be the main endpoint analysed. The survey will collect historically documented visual acuity data for all patients at participating sites with a genetically confirmed diagnosis of LHON. No exclusion criteria apply. Patients are not required to attend the clinic for the survey. Data will be collected in a completely anonymous manner. Ethical approvals and data release agreements will be obtained as required by local regulations.
Study Type
OBSERVATIONAL
Enrollment
306
University Hospitals Leuven
Leuven, Belgium
Glostrup Hospital/National Eye Clinic of the Kennedy Center/University of Copenhagen Department of Ophthalmology
Glostrup Municipality, Denmark
CHU Bordeaux
Bordeaux, France
CIC/CMR CHNO des Quinze-Vingts
Paris, France
Universty of Bari
Bari, Italy
Fondazione G.B. Bietti
Rome, Italy
San Raffaele Hospital
Segrate, Italy
University Eye Clinic
Ljubljana, Slovenia
Visual acuity
The Entire duration of the disease patient by patient basis up to the date of completion of the Case Report Form (CRF).
Time frame: average 0 to 10 years (retrospective)
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