Safety and Tolerability Study of EG-1962 in Aneurysmal Subarachnoid Hemorrhage

Inclusion Criteria: * Male or female between the ages of 18 to 75 years, inclusive; * WFNS Grade 2, 3, or 4 assessed after treatment of the aneurysm but prior to administration of EG-1962; * Ruptured saccular aneurysm confirmed by angiography (catheter or CTA) and treated by neurosurgical clipping or endovascular coiling; * Subarachnoid hemorrhage on baseline CT scan that is diffuse (clot present in both hemispheres) thick (\>4 mm) or thin, or local thick; * External ventricular drain (EVD) in place; * The patient is able to receive EG-1962 within 60 hours of the onset of subarachnoid hemorrhage (SAH). Onset of SAH is defined as the time the patient experiences the first symptom of SAH (e.g., severe headache or loss of consciousness reported either by patient or by a witness). If found unconscious, the onset of SAH is defined as the last time the patient was seen at baseline neurological state; * Weight \>45 kg; * Hemodynamically stable after resuscitation with systolic blood pressure (SBP) ≥90 mm Hg without the use of inotropic agents; * Signed informed consent from the patient or the patient's legal representative after the completion of aneurysm repair and after all study criteria are confirmed; and * Female patients of child bearing potential must have negative pregnancy test . Male patients must agree to use adequate birth control during the study and up to 1 month after the discontinuation of the study drug treatment. Exclusion Criteria: * Subarachnoid hemorrhage due to causes other than a saccular aneurysm (e.g., trauma or rupture of fusiform or infective aneurysm); * WFNS Grade 1 or 5 assessed after completion of the aneurysm repair but prior to administration of EG-1962; * Increased intracranial pressure \>30 mm Hg in sedated patients lasting \>4 hours anytime since admission; * Intraventricular or intracerebral hemorrhage in absence of SAH or with only local, thin SAH; * Angiographic vasospasm prior to aneurysm repair procedure, as documented by catheter angiogram or CT angiogram; * Major complication during aneurysm repair such as, but not limited to, massive intraoperative hemorrhage, brain swelling, arterial occlusion, or inability to secure the ruptured aneurysm; * Aneurysm repair requiring flow diverting stent or stent-assisted coiling and dual antiplatelet therapy; * Hemodynamically unstable prior to administration of study drug (i.e., SBP \<90 mm Hg, requiring \>6 L colloid, or crystalloid fluid resuscitation; * Cardiopulmonary resuscitation was required following SAH; * Female patients with positive pregnancy test (blood or urine) at screening; * History within the past 6 months and/or physical finding on admission of decompensated heart failure (New York Heart Association Class III and IV or heart failure requiring hospitalization); * Acute myocardial infarction within 3 months prior to the administration of the study drug; * Symptoms or electrocardiogram (ECG)-based signs of acute myocardial infarction or unstable angina pectoris on admission; * Electrocardiogram evidence and/or physical findings compatible with second or third degree heart block or of cardiac arrhythmia associated with hemodynamic instability; * Echocardiogram, if performed as part of standard-of-care before treatment, revealing a left ventricular ejection fraction \<40%; * Severe or unstable concomitant condition or disease (e.g., known significant neurologic deficit, cancer, hematologic, or coronary disease), or chronic condition (e.g., psychiatric disorder), that, in the opinion of the Investigator, may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results; * Patients who have received an investigational product or participated in another interventional clinical study within 30 days prior to randomization. Patients participating in a non-interventional study that has no bearing on assessment of EG-1962 or enteral nimodipine can be enrolled per guidelines of the local Institutional Review Board (IRB) / independent Ethics Committee (IEC). * Kidney disease as defined by plasma creatinine ≥2.5 mg/dl (221 μmol/l); liver disease as defined by total bilirubin \>3 mg/dl (51.3 μmol/l); and/or known diagnosis or clinical suspicion of liver cirrhosis; or Known hypersensitivity to nimodipine or other dihydropyridine calcium channel antagonists, poly-D, L-lactide-co-glycolide (PLGA), or hyaluronic acid.