Until now, no specific atherosclerosis-targeting agent labeled with positron emitter is not yet available. Investigators developed neomannosyl human serum albumin(MSA) for the terminal mannose residues of MSA binding with the mannose receptors of macrophages in atherosclerosis, and investigators investigate whether 68Ga-MSA can be a novel agent for non-invasive molecular imaging of carotid atherosclerotic lesion in PET.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Enrollment
12
68Gallium-MSA 2.0 mci for Positron Emission Tomogram(PET) imaging
Department of Nuclear Medicine, Institute of Radiation Medicine,
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
side reactions at MSA injection site of the skin
development of unexpected skin rashes or other skin lesions at MSA injection site of the skin with 2 hours after MSA injection
Time frame: with 2 hours after MSA injection
unstable changes of vital signs and development of abnormal biochemical parameters
This includes unstable changes of vital signs including blood pressure, body temperature and heart rate, and abnormal changes of biochemical parameters such as hematologic, hepatic and renal functions.
Time frame: 24 hours after MSA injection
standard uptake unit(SUV) at carotid arteries
Time frame: baseline
SUV at aorta and iliac arteries
Time frame: baseline
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