Effect on Blood Flow Using the FlowOx™ Device in Patients With Reduced Peripheral Circulation in the Lower Leg

Inclusion Criteria: * Written Informed Consent * Age 30-90 years * Affected foot/shoe sise less than 46 (approximate foot length less than 29.5 cm) * Patients with Peripheral Arterial Occlusive Disease (PAOD) grade 2,3 or 4, i.e.: 1. Clinically verified grade 2, i.e. Intermittent Claudication: * Ancle-Brachial Index (ABI)less than 0.9 or * Toe brachial Index (TBI) less than 0.7 or * Ultrasound and/or CT/Magnetic Resonance (MR) angiography suggesting stenosis(es)and/or occlusion(s) 2. Clinically verified grade 3, i.e. Critical Limb Ischemia (CLI): * ABI less than 0.4 or * Toe pressure less than 30 mmHg * Rest pain since at least 2 weeks or * Use of analgesics for rest pain for at least 2 weeks or * Ultrasound and/or CT/Magnetic Resonance (MR) angiography suggesting stenosis(es)and/or occlusion(s) 3. Clinically verified grade 4, i.e. CLI: * Ischemic ulcers or gangrene/tissue loss * ABI less than 0.4 * Toe pressure less than 30 mmHg * Rest pain since at least 2 weeks or * Use of analgesics for rest pain for at least 2 weeks or * Ultrasound and/or CT/MR angiography suggesting stenosis(es)and/or occlusion(s) Exclusion Criteria: * Grade 1 PAOD * Incapable of consenting voluntarily * Fewer higher than 39 degrees Centigrade * Severe Chronic Obstructive Pulmonary Disease (COPD) * Severe heart disease such as unstable angina, severe heart failure and severe valve failure * Severe Polyneurophathy * Verified Osteomyelitis other than in the Phanlanx * Currently treated for cancer and With a life expectancy of less than 2 years