The investigators have previously shown the intact protein from cod filet improves glucose regulation and serum lipid profile in overweight adults. A large amount of trimmings from various fish species such as cod is thrown away or sold at very low prices for animal feed, and analyses of the amino acid composition reveals that this can be a good protein source for humans. Two fractions are normally isolated from intact fish meal, i.e. water soluble and non-water soluble proteins. In the present study the investigators will compare these fractions, by studying their effects on glucose regulation in overweight/obese adults.
Participants receive 6g per day of water soluble on non-water soluble cod protein as tablets for 8 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
55
6g protein per day for 8wk
6 g protein per day for 8 wk
University of Bergen
Bergen, Norway
Glucose tolerance
Serum glucose will be measured in fasting and postprandial state
Time frame: 8 weeks
Gene expression
Changes in gene expression in adipose tissue related to the circulating markers of glucose regulation.
Time frame: 8 weeks
Amino acids and amino acid metabolites
Amino acids and amino acid metabolites will be measured in serum and urine
Time frame: 8 weeks
Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine
Concentrations of relevant metabolites and co-factors were measured in serum and urine
Time frame: 8 weeks
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