Efficacy Study of Pentosan Polysulfate Sodium,Hydrodistension and Combination Therapy for Bladder Pain Syndrome

Inclusion Criteria: 1. men and women who were over 18 years old and had symptoms over 6 months. 2. 4 or more with an pain visual analogue score 3. 12 or more O'Leary-Sant Intersttial Cystitis questionnaire (IC-Q) symptom and problem score and with a pain score and nocturia score of 2 or more. Exclusion Criteria: 1. history of hydrodistention,augumentation cystoplasty due to IC/BPS 2. pentosan polysulfate sodium (Elmiron) history over 1 month within 6 months. 3. Women of child-bearing potential who were pregnant or nursing 4. mean voided volume lesser than 40ml or over than 400ml. 5. hematuria exceeds 1+ in the urinary dipstick (dipstick) examination. 6. urinary tract infection during run-in periods. 7. genitourinary tuberculosis or bladder,urethral and prostate cancer 8. recurrent urinary tract infection 9. history of hystrectomy,mid-urethral sling,pelvic organ prolapse repair,vaginal delivery or Cesarean section,prostate opreation or treatment etc within 6months. 10. neurologic disease history of cerebral infaction,multiple sclerosis or parkinsonism etc.