Safety and Efficacy Study of Autologus Bone Marrow Mesenchymal Stem Cells in Multiple Sclerosis

Inclusion Criteria: * A clinical diagnosis of definite MS according to the revised McDonald Criteria. * Expanded Disability Status Scale (EDSS) ≤ 6 * Failure of standard medical therapy * Disease duration of at least three years prior to enrollment. Exclusion Criteria: * Pregnant and lactating women * Previous treatment with immunosuppressive agents in the last 12 months prior to enrollment * Recent MS relapse in the month prior to enrollment * Treatment with oral or parenteral steroids for any cause in the month prior to enrollment * Significant systemic medical disorders including cardiac, renal, hepatic, hematologic, immunologic or endocrine disorders * Previous treatment with interferons or glatiramer acetate in the 3 months prior to enrollment * Any contra-indication for magnetic resonance imaging (MRI) or gadolinium contrast. * Positive serology for HIV, Hepatitis B or Hepatitis C * Any history of malignancy or exposure to radiation at any time prior to enrollment * Any contra-indication to lumbar puncture * Severe cognitive impairment that would interfere with the patient's ability to understand and sign the informed consent.