Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS)

Inclusion Criteria: * Subject 18 years of age or older * Able and willing to give written informed consent and to comply with the requirements of the study protocol * Subject met the definition of Ankylosing Spondylitis (AS) based on ASAS Criteria * Subject with active AS, has had an inadequate response, an intolerance or an to one or more nonsteroidal anti-inflammatory drugs Exclusion Criteria: * Previous adalimumab treatment or previous treatment with more than one anti TNF alpha therapy. * Previous methotrexate treatment, not stopped 3 month before inclusion * Surgery scheduled during study * Female subject without method of contraception * Contraindication to adalimumab or methotrexate