Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow by Hypoxia

Danish Headache Center34 enrolled

Overview

In this study the investigators will investigate the following hypothesis * that hypoxia induce migraine headache and migraine aura * the aura phase is associated with a spreading reduction in cerebral blood flow * the migraine headache is associated with dilatation of intra- and extracerebral arteries * the migraine headache is associated with changes in brain metabolism * the pre-ictal stage of a migraine attack with aura is associated with specific patterns in neural activity.

To investigate migraine with aura symptoms during and after hypoxia. With magnetic resonance imaging the investigators will investigate changes in * regional cerebral blood flow (rCBF) * resting state functional connectivity * circumference of the middle cerebral artery(MCA), internal carotic artery, superficial temporal artery, medial meningeal artery, external carotic artery * brain metabolism And compare these changes with a aged match healthy control group.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Headache Migraine Aura

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Migraine with aura patients and Helthy volunteers as controls: * Aged 18-40 * 50-100 kg Exclusion Criteria: * Tension type headache more than 5 days/month * Other primary headaches * Daily medication except contraceptives * Drug taken within 4 times the halflife for the specific drug except contraceptives * Pregnant or lactating women * Headache or migraine attack within the last 48 hours before start of trial * Hypertension * Hypotension * Respiratory or cardiac disease * smoking Extra exclusion Criteria for healthy volunteers: * migraine at present or earlier in life * parents, sibling or children who suffer or have suffered from migraine

Outcomes

Primary Outcomes

Headache and aura

Comparison between hypoxia and placebo (atmospheric air)

Time frame: 24 h

Secondary Outcomes

artery circumference

Hypoxia induced changes in intra- and extracranial circumference

Time frame: Baseline, 120 and 200 min

Cerebral blood flow

Hypoxia induced changes in cerebral blood flow

Time frame: Baseline, 120 and 200 min

BOLD response in visual cortex

Hypoxia induced changes in BOLD response

Time frame: Baseline, 170 min and 220 min

Brain metabolism

Hypoxia induced changes in brain metabolism

Time frame: Baseline, 180 min and 230 min post hypoxia