Trial Comparing the Efficacy, Tolerability and Safety Between Three Arms in Treatment of HCV in Egyptian Population

Inclusion Criteria: 1. The subject signs and dates a written informed consent form (ICF) prior to any study-related activities, including discontinuation of any prohibited medications. 2. If the subject is male and sexually active, he is eligible to enter and participate in this study if his partner(s) meet the criteria outlined in 2a or if he or his partner(s) are using one of the methods of birth control outlined in 2b. If the subject is female, she is eligible to enter and participate in this study if she meets the following criteria: 1. Non-childbearing potential (i.e., physiologically incapable of becoming pregnant, including any female who is postmenopausal; for purposes of this study, postmenopausal is defined as 1 year without menses); or 2. Childbearing potential, has a negative serum pregnancy test at screening. 3. The subject is between the ages of 20 and 50, inclusive at the time of the screening visit. 4. The subject is an ambulatory outpatient. Ambulatory is defined as not depending exclusively on a wheelchair for mobility. Nursing home subjects may be enrolled provided they are ambulatory. Subjects with spinal cord injuries resulting in paraplegia may not be enrolled. 5. The subject is or has been diagnosed with Hepatitis C genotype 4. 6. Subjects are treatment Naive 7. Male or female subjects with BMI ≤ 35 . 8. Compensated liver disease with all the following minimum hematological and biochemical criteria: 1. Hemoglobin \> 12 g/dl for males, \>11 g/dl for females. 2. White blood cell count (WBC) \> 3,000 /mm3 - Absolute Neutrophilic count (ANC above 1000) 3. Platelets \> 80,000/mm3 4. Prothrombin time less than 4 seconds above the upper limit of normal (ULN). 5. Serum albumin \> 3.5mg/dl 6. Normal Bilirubin level (except for Gilbert's syndrome where indirect Bilirubin should be \< 3mg/dl) 7. Histological diagnosis of chronic hepatitis with Fibroscan( fibrosis assessment). 8. Normal fasting blood glucose level or within 20% of ULN for non-diabetic patients. If there is a history of diabetes, hemoglobin A1C \<8.5% (as evidence of good glucose control in recent months). 9. Serum Creatinine within normal limits. 10. Thyroid Stimulating Hormone (TSH) within normal limits of testing lab. Patients requiring medications to maintain TSH are eligible if they have fulfilled all other inclusion and exclusion criteria. 11. Alpha Fetoprotein within normal range obtained during one year prior to entry in the study. Results above the upper limit of normal but less than 100 units require both of the following: 1. Alpha Fetoprotein obtained within 3 months of entry. 2. Abdominal Ultrasound within 3 months of entry that is negative for evidence of hepatocellular carcinoma. 3. If Alpha Fetoprotein is above 100 units CT scan of the abdomen that is negative for evidence of hepatocellular carcinoma is required. 12. Patients must be serum hepatitis B surface antigen (HBsAg) negative. 13. Negative Antinuclear Antibodies (ANA) or titer of \< 1:160 14. Serum positive for anti-HCV antibodies and HCV-RNA. 15. Abdominal Ultrasound obtained within one year prior to entry in the study 16. Electrocardiogram for men aged \> 40 years. 17. Normal urine analysis. 18. Normal fundus exam. 19. Serum Schistosoma antibody test, if positive \> 1/80, a rectal biopsy is required. If rectal biopsy is positive to living Schistosomal eggs, treatment of Active Schistosomal disease is required one month prior to enrollment. Exclusion Criteria: 1. The subject has been diagnosed with HBV or HCV of any genotype other than genotype 4 and /or HIV. 2. Subjects are older than 50 years or younger than 20 years of age. 3. Women who are pregnant or breast-feeding. 4. Suspected hypersensitivity to Interferon or Ribavirin. 5. Subjects with organ transplant other than corneal or hair transplant. 6. Any cause of the liver disease based on the patient's history and biopsy other than chronic hepatitis C genotype 4, including but not limited to: 1. Alpha 1-antitrypsin deficiency. 2. Wilson's disease. 3. Liver transplant patients. 4. Autoimmune hepatitis. 5. Alcoholic liver disease. 6. Obesity induced disease. 7. Drug related liver disease. 8. Co-infection with Hepatitis B Virus (HBV) or HIV (HBsAg or HIV antibodies positivity). 9. Hemochromatosis (iron deposition more than 2+ in liver parenchyma) 10. Evidence of advanced liver disease such as history or presence of ascitis, bleeding varices, spontaneous encephalopathy. 7. In the opinion of the investigator, the subject has a concurrent illness or disability (excluding HCV genotype 4) that may affect the interpretation of clinical efficacy and/or safety data or otherwise contraindicates participation in this clinical study ; 1. Unstable pulmonary, endocrine \& metabolic disorders e.g. poorly controlled diabetes. 2. Subjects with hemophilia or any hemoglobinopathy including but not limited to thalassemia major or minor. 3. Bone marrow compromise contraindicated for interferon treatment 4. Central Nervous System (CNS) trauma or active seizures that require medications. 5. The subject exhibits renal impairment as evidenced by a serum Creatinine higher than 2.0 mg/dL. Or history of Chronic renal failure 6. Immunologically mediated diseases (e.g. inflammatory bowel disease, idiopathic thrombocytopenic purpura, systemic lupus erythromatosis, autoimmune hemolytic anemia, scleroderma, severe psoriasis, clinical cryoglobulinemia) 7. Any medical condition requiring or likely to require during course of the study, chronic systemic administration of steroids. 8. Patients with clinically significant retinal abnormalities. 9. The subject has a history of unstable or deteriorating cardiac disease within the previous 6 months, including, but not limited to, the following: i. Myocardial infarction, unstable angina pectoris, coronary artery bypass surgery, or coronary angioplasty ii. Congestive heart failure requiring hospitalization iii. Uncontrolled arrhythmias 8. The subject has been diagnosed with a major psychiatric disorder (e.g., major depression or psychoses) within the past 2 years that required hospitalization and/or involved an attempted suicide. Subjects diagnosed with a major psychiatric disorder that did not require hospitalization or involve an attempted suicide must have remained on a stable dose of medication for at least 6 months prior to the screening visit. 9. The subject has a history of alcohol or substance abuse within the past 2 years. 10. The subject has a positive stool sample for ova or parasite (exception: the finding of Entamoeba coli is not exclusionary). 11. The subject has any evidence or treatment of malignancy (other than localized basal cell cancer, squamous cell skin cancer, or cancer in situ that has been resected) within the previous 5 years. 12. The subject used an investigational drug or participated in an investigational study within 30 days of screening. 13. The subject refuses to discontinue one (or more) prohibited medications at least 7 days prior to the screening visit. 14. The subject refuses to maintain a stable dose of one (or more) allowable concurrent medications for at least 30 days prior to the screening visit. 15. The subject is unable or unwilling to follow directions. 16. Contraindications to ribavirin and thus combination therapy include marked anemia, renal dysfunction, and coronary artery or cerebrovascular disease, and inability to practice birth control.