The Safety and Efficacy of a Peanut Immunotherapy Dissolving Film for Peanut Allergy

Inclusion Criteria: * Age 18 to 50 years * Provide signed informed consent * Using appropriate birth control if subject is female and of child bearing age * Are available for the study duration Healthy Volunteers Only * Regularly consume a meal sized portion (5 grams) of peanut at least twice per month during the proceeding 6 months Peanut Allergic Subjects Only * Have a history of symptomatic reactivity to peanut * Have a positive skin prick test * Have a positive oral food challenge to peanut at a cumulative dose of less than 1 grams of peanut protein * Have self-injectable epinephrine available at home Exclusion Criteria: * Have a history of severe anaphylaxis to peanut, defined as hypoxia, hypotension or neurological compromise as a result of ingestion of peanut. * Have a history of intubation related to asthma * Are pregnant or lactating * Have a viral Upper Respiratory Infection (URI) or gastroenteritis within 7 days of Oral food challenge * Have pulmonary function tests \<80% of predicted (FEV1) or clinical history consistent with more than moderate persistent asthma * Are currently taking greater than medium dose inhaled corticosteroid (\>500 mcg/day fluticasone or fluticasone equivalent) * Are unable to discontinue antihistamines for 5 days for long acting and 3 days for short acting prior to skin testing or food challenges * Have used systemic corticosteroids within 4 weeks prior to baseline visit * Are receiving omalizumab, beta-blocker, Angiotensin Converting Enzyme (ACE) inhibitor or tricyclic antidepressant therapy. Subjects need to be off omalizumab for 6 months. * Have history of oral cancer. * Use oral tobacco (i.e., chew tobacco) * Have a chronic disease (other than asthma, atopic dermatitis or rhinitis) requiring therapy (e.g., heart disease, diabetes) * Have participated in any interventional study for treatment of a food allergy in the past 12 months * Have a history of eosinophilic esophagitis * Have a severe reaction at initial double blind placebo-controlled food challenge, defined as either: * Life-threatening anaphylaxis, or * Reaction requiring hospitalization Healthy Volunteers Only * History of any allergy to peanut